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Heat fluxes in the data center have been increasing significantly due to the rise in advanced technologies such as Artificial Intelligence (AI), 5G, high-performance computing (HPC), and machine learning. The traditional air-cooling technology cannot handle high heat fluxes and requires a bigger heat sink; therefore, hindering high heat flux and high density in the data center. Two-phase cooling schemes are particularly appropriate for high heat flux situations because of their enhanced heat transfer coefficients and the non-linear relationship between heat flux and surface-to-fluid temperature difference. In this study, an experimental setup was developed to characterize and optimize the thermo-hydraulic performance of two-phase cooling cold plates intended for high heat flux applications. An improvement of 12% in thermal performance was obtained by cutting the original fins and creating mini-channels perpendicular to the original microchannels without a significant pressure drop penalty.